Characteristics and Biological Variations of M-Ficolin, a Pattern Recognition Molecule, in Plasma
نویسندگان
چکیده
منابع مشابه
Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma.
The three human ficolins, H-ficolin, L-ficolin and M-ficolin, are pattern recognition molecules of the innate immune system. All three ficolins can activate the lectin pathway of the complement system after binding to pathogens. H- and L-ficolin are serum proteins with an average concentration of 18 and 3 microg/ml, respectively. M-ficolin has been described as a membrane-associated pattern rec...
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Ficolins are pattern recognition molecules of the innate immune system. H-ficolin is found in plasma associated with mannan-binding lectin-associated serine proteases (MASPs). When H-ficolin binds to microorganisms the MASPs are activated, which in turn activate the complement system. H-ficolin is the most abundant ficolin in humans, yet its ligand binding characteristics and biological role re...
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ژورنال
عنوان ژورنال: Journal of Innate Immunity
سال: 2010
ISSN: 1662-8128,1662-811X
DOI: 10.1159/000218324